Promising Anticancer Activity of [Bis(1,8-quinolato)palladium (II)] Alone and in Combination.

ABSTRACT: Due to similar coordination chemistry of palladium and platinum, a large number of palladium compounds as well have been investigated for their anticancer activity. In the present study, we describe synthesis, characterization, and anticancer activity of palladium complex [Bis(1,8-quinolato)palladium (II)], coded as NH3 against seven different cancer cell lines. NH3 is found to have higher antitumor activity than cisplatin against both parent ovarian A2780 cell line and cisplatin-resistant cell lines. Also, NH3 has the lower IC50 value in HT-29 colorectal cancer cell line. The higher antitumor activity of NH3 is due to the presence of bulky 8-Hydroxyquinoline ligand, thus reducing its reactivity. Proteomic study has identified significantly expressed proteins which have been validated thro

SUBMITTER: Alam MN 

PROVIDER: S-EPMC8395214 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature