3q26 Amplifications in Cervical Squamous Carcinomas.

ABSTRACT:

Background

Squamous carcinomas of the uterine cervix often carry mutations of the gene encoding for the catalytic sub-unit of kinase PI3K, PIK3CA. The locus of this gene at chromosome 3q26 and neighboring loci are also commonly amplified. The landscape of 3q26-amplified cases have not been previously characterized in detail in cervical cancer.

Methods

Published genomic data and associated clinical data from TCGA cervical cancer cohort were analyzed at cBioportal for amplifications in genes at 3q26. The clinical and molecular characteristics of the group of patients with 3q26 amplifications was compared with the group without 3q26 amplifications. Comparative prevalence of amplification and expression of genes at 3q26 in amplified squamous cervical cancer cases were sur

SUBMITTER: Voutsadakis IA 

PROVIDER: S-EPMC8395483 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature