Palladium-Catalyzed Regioselective Arylation of Unprotected Allylamines.

ABSTRACT: Palladium-catalyzed organometallic transformations of free amines are often unsuccessful due to side reactions, such as oxidation, that can occur. However, the ability to furnish the free amine products from these reactions is important for improving the utility and sustainability of these processes, especially for accessing their potential as medicinal and agrochemical agents. Notably, the 3,3-diarylallylamine motif is prevalent in a variety of biologically relevant structures, yet there are few catalytic approaches to their synthesis, and none involving the free amine. Herein, we describe a simple protocol for the arylation of cinnamylamines and the diarylation of terminal allylamines to generate a diverse group of 3,3-diarylallylamine products using a Pd^II precatalyst. Key fe

SUBMITTER: Landge VG 

PROVIDER: S-EPMC8395680 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature