Endogenous Conjugation of Biomimetic Dinitrosyl Iron Complex with Protein Vehicles for Oral Delivery of Nitric Oxide to Brain and Activation of Hippocampal Neurogenesis.

ABSTRACT: Nitric oxide (NO), a pro-neurogenic and antineuroinflammatory gasotransmitter, features the potential to develop a translational medicine against neuropathological conditions. Despite the extensive efforts made on the controlled delivery of therapeutic NO, however, an orally active NO prodrug for a treatment of chronic neuropathy was not reported yet. Inspired by the natural dinitrosyl iron unit (DNIU) [Fe(NO)₂], in this study, a reversible and dynamic interaction between the biomimetic [(NO)₂Fe(μ-SCH₂CH₂OH)₂Fe(NO)₂] (DNIC-1) and serum albumin (or gastrointestinal mucin) was explored to discover endogenous proteins as a vehicle for an oral delivery of NO to the brain after an oral administration of DNIC-1. On t

SUBMITTER: Wu CR 

PROVIDER: S-EPMC8395708 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature