Ontology highlight
ABSTRACT:
SUBMITTER: Lange M
PROVIDER: S-EPMC8395730 | biostudies-literature | 2021 Aug
REPOSITORIES: biostudies-literature
Lange Marios M Begolli Rodiola R Giakountis Antonis A
Non-coding RNA 20210802 3
The cancer genome is characterized by extensive variability, in the form of Single Nucleotide Polymorphisms (SNPs) or structural variations such as Copy Number Alterations (CNAs) across wider genomic areas. At the molecular level, most SNPs and/or CNAs reside in non-coding sequences, ultimately affecting the regulation of oncogenes and/or tumor-suppressors in a cancer-specific manner. Notably, inherited non-coding variants can predispose for cancer decades prior to disease onset. Furthermore, ac ...[more]