Formulation and Characterization of a New Injectable Bone Substitute Composed PVA/Borax/CaCO₃ and Demineralized Bone Matrix.

ABSTRACT: The occurrence of bone-related disorders and diseases has dramatically increased in recent years around the world. Demineralized bone matrix (DBM) has been widely used as a bone implant due to its osteoinduction and bioactivity. However, the use of DBM is limited because it is a particulate material, which makes it difficult to manipulate and implant with precision. In addition, these particles are susceptible to migration to other sites. To address this situation, DBM is commonly incorporated into a variety of carriers. An injectable scaffold has advantages over bone grafts or preformed scaffolds, such as the ability to flow and fill a bone defect. The aim of this research was to develop a DBM carrier with such viscoelastic properties in order to obtain an injectable bone substitute (IBS)

SUBMITTER: Medrano-David D 

PROVIDER: S-EPMC8395841 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature