Effects of Rapamycin on Insulin Brain Endothelial Cell Binding and Blood-Brain Barrier Transport.

ABSTRACT: Rapamycin is an exogenous compound that has been shown to improve cognition in Alzheimer's disease mouse models and can regulate pathways downstream of the insulin receptor signaling pathway. Insulin is also known to improve cognition in rodent models of Alzheimer's disease. Central nervous system (CNS) insulin must first cross the blood-brain barrier (BBB), a specialized network of brain endothelial cells. This transport process is regulated by physiological factors, such as insulin itself, triglycerides, cytokines, and starvation. Since rapamycin treatment can alter the metabolic state of rodents, increase the circulating triglycerides, and acts as a starvation mimetic, we hypothesized rapamycin could alter the rate of insulin transport across the BBB, providing a potential mechanism for

SUBMITTER: Nguyen S 

PROVIDER: S-EPMC8395935 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature