Memory in multiple sclerosis: A reappraisal using the item specific deficit approach.

ABSTRACT:

Objective

As many as 65% of people with multiple sclerosis (MS) have clinically significant memory impairment, but the nature of this deficit is controversial. Some investigations suggest that an inability to retrieve newly learned information from memory is prominent, whereas others imply that compromised acquisition accounts for impairment. Prior research has not simultaneously evaluated acquisition and retrieval processes in MS, and fewer have attempted to account for initial acquisition when studying retrieval. The Item Specific Deficit Approach (ISDA) offers a method of quantifying acquisition, retrieval, and retention processes, with the latter two mechanisms being adjusted for initial acquisition. To simultaneously quantify acquisition and retrieval abilities, the ISDA was a

SUBMITTER: Basso MR 

PROVIDER: S-EPMC8396077 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature