Distinct Symptom-Specific Treatment Targets for Circuit-Based Neuromodulation.

ABSTRACT:

Objective

Treatment of different depression symptoms may require different brain stimulation targets with different underlying brain circuits. The authors sought to identify such targets, which could improve the efficacy of therapeutic brain stimulation and facilitate personalized therapy.

Methods

The authors retrospectively analyzed two independent cohorts of patients who received left prefrontal transcranial magnetic stimulation (TMS) for treatment of depression (discovery sample, N=30; active replication sample, N=81; sham replication sample, N=87). Each patient's TMS site was mapped to underlying brain circuits using functional connectivity MRI from a large connectome database (N=1,000). Circuits associated with improvement in each depression symptom were identified and

SUBMITTER: Siddiqi SH 

PROVIDER: S-EPMC8396109 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature