Insights into the Role of Membrane Lipids in the Structure, Function and Regulation of Integral Membrane Proteins.

ABSTRACT: Membrane proteins exist within the highly hydrophobic membranes surrounding cells and organelles, playing key roles in cellular function. It is becoming increasingly clear that the membrane does not just act as an appropriate environment for these proteins, but that the lipids that make up these membranes are essential for membrane protein structure and function. Recent technological advances in cryogenic electron microscopy and in advanced mass spectrometry methods, as well as the development of alternative membrane mimetic systems, have allowed experimental study of membrane protein-lipid complexes. These have been complemented by computational approaches, exploiting the ability of Molecular Dynamics simulations to allow exploration of membrane protein conformational changes in membranes

SUBMITTER: Renard K 

PROVIDER: S-EPMC8396450 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature