Nitro-Oleic Acid (NO₂-OA) Improves Systolic Function in Dilated Cardiomyopathy by Attenuating Myocardial Fibrosis.

ABSTRACT: Nitro-oleic acid (NO₂-OA), a nitric oxide (NO)- and nitrite (NO₂^-)-derived electrophilic fatty acid metabolite, displays anti-inflammatory and anti-fibrotic signaling actions and therapeutic benefit in murine models of ischemia-reperfusion, atrial fibrillation, and pulmonary hypertension. Muscle LIM protein-deficient mice (Mlp^-/-) develop dilated cardiomyopathy (DCM), characterized by impaired left ventricular function and increased ventricular fibrosis at the age of 8 weeks. This study investigated the effects of NO₂-OA on cardiac function in Mlp^-/- mice both in vivo and in vitro. Mlp^-/- mice were treated with NO₂-OA or vehicle for 4 weeks via subcutaneous osmotic minipumps. Wildty

SUBMITTER: Braumann S 

PROVIDER: S-EPMC8396484 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature