Characterization of linear epitope specificity of antibodies potentially contributing to spontaneous clearance of hepatitis C virus.

ABSTRACT:

Background

Around 30% of the HCV infected patients can spontaneously clear the virus. Cumulative evidence suggests the role of neutralizing antibodies in such spontaneous resolution. Understanding the epitope specificity of such antibodies will inform the rational vaccine design as such information is limited to date. In addition to conformational epitope targeted antibodies, linear epitope specific antibodies have been identified that are broadly cross reactive against diverse HCV strains. In this study, we have characterized the potential role of three conserved linear epitopes in the spontaneous clearance of HCV.

Methods

We tested the reactivity of sera from chronic patients (CP) and spontaneous resolvers (SR) with linear peptides corresponding to three conserved regions

SUBMITTER: Ahsan A 

PROVIDER: S-EPMC8396737 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature