Automated home-cage monitoring as a potential measure of sickness behaviors and pain-like behaviors in LPS-treated mice.

ABSTRACT: The use of endotoxin, such as lipopolysaccharide (LPS) as a model of sickness behavior, has attracted recent attention. To objectively investigate sickness behavior along with its pain-like behaviors in LPS-treated mice, the behavioral measurement requires accurate methods, which reflects clinical relevance. While reflexive pain response tests have been used for decades for pain assessment, its accuracy and clinical relevance remain problematic. Hence, we used automated home-cage monitoring LABORAS to evaluate spontaneous locomotive behaviors in LPS-induced mice. LPS-treated mice displayed sickness behaviors including pain-like behaviors in automated home-cage monitoring characterized by decreased mobile behaviors (climbing, locomotion, rearing) and increased immobility compared to that of

SUBMITTER: Hasriadi 

PROVIDER: S-EPMC8396795 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature