Failure of High-Flow Nasal Cannula Therapy in Pneumonia and Non-Pneumonia Sepsis Patients: A Prospective Cohort Study.

ABSTRACT: Despite the increasing use of high-flow nasal cannulas (HFNCs) to treat critically ill patients, data on their effectiveness for sepsis patients remains very limited. We studied a prospective cohort of sepsis patients from the Korean Sepsis Registry (18 intensive care units (ICUs)). Patients started on HFNC therapy for hypoxemia within the first three ICU days were enrolled. HFNC failure was defined as intubation or ICU death, and the primary outcome was early HFNC failure occurring within 72 h of HFNC initiation. Of 901 patients with sepsis admitted to the ICU, 206 who received HFNC therapy were finally included (117 with pneumonia vs. 89 with non-pneumonia sepsis; median age, 71.0 (63.0-78.0) years; PaO2/FiO2 ratio, 160.2 (107.9-228.2) mm Hg; septic shock, n = 81 (39.3%)). During HFNC th

SUBMITTER: Kim E 

PROVIDER: S-EPMC8396877 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature