Evaluation of Total Female and Male Aedes aegypti Proteomes Reveals Significant Predictive Protein-Protein Interactions, Functional Ontologies, and Differentially Abundant Proteins.

ABSTRACT: Aedes aegypti is a significant vector for many tropical and subtropical flavivirus diseases. Only the female mosquito transmits pathogens, while the male plays a vital role in mating and species continuity. This study explored the total proteomes of females and males based on the physiological and genetic differences of female and male mosquitoes. Protein extracts from mosquitoes were analysed using LC-ESI-MS/MS for protein identification, protein interaction network analysis, functional ontology enrichment, and differential protein abundance analyses. Protein identification revealed 422 and 682 proteins exclusive to males and females, respectively, with 608 common proteins found in both sexes. The most significant PPIs (<1.0 × 10^-16) were for common proteins, followed by

SUBMITTER: Shettima A 

PROVIDER: S-EPMC8396896 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature