Mechanisms of Azole Resistance and Trailing in Candida tropicalis Bloodstream Isolates.

ABSTRACT:

Objectives

Azole-resistant Candida tropicalis has emerged in Asia in the context of its trailing nature, defined by residual growth above minimum inhibitory concentrations (MICs). However, limited investigations in C. tropicalis have focused on the difference of genotypes and molecular mechanisms between these two traits.

Methods

Sixty-four non-duplicated C. tropicalis bloodstream isolates collected in 2017 were evaluated for azole MICs by the EUCAST E.def 7.3.1 method, diploid sequence type (DST) by multilocus sequencing typing, and sequences and expression levels of genes encoding ERG11, its transcription factor, UPC2, and efflux pumps (CDR1, CDR2 and MDR1).

Results

Isavuconazole showed the highest in vitro act

SUBMITTER: Chen PY 

PROVIDER: S-EPMC8396981 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature