Kinetic Resolution of Racemic Mixtures via Enantioselective Photocatalysis.

ABSTRACT: Despite the increasing demand for enantiopure drugs in the pharmaceutical industry, currently available chiral separation technologies are still lagging behind, whether due to throughput or to operability considerations. This paper presents a new kinetic resolution method, based on the specific adsorption of a target enantiomer onto a molecularly imprinted surface of a photocatalyst and its subsequent degradation through a photocatalytic mechanism. The current model system is composed of an active TiO₂ layer, on which the target enantiomer is adsorbed. A photocatalytic suppression layer of Al₂O₃ is then grown around the adsorbed target molecules by atomic layer deposition. Following the removal of the templating molecules, molecularly imprinted cavities tha

SUBMITTER: Arbell N 

PROVIDER: S-EPMC8397234 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature