Fast Ion-Chelate Dissociation Rate for In Vivo MRI of Labile Zinc with Frequency-Specific Encodability.

ABSTRACT: Fast ion-chelate dissociation rates and weak ion-chelate affinities are desired kinetic and thermodynamic features for imaging probes to allow reversible binding and to prevent deviation from basal ionic levels. Nevertheless, such properties often result in poor readouts upon ion binding, frequently result in low ion specificity, and do not allow the detection of a wide range of concentrations. Herein, we show the design, synthesis, characterization, and implementation of a Zn²⁺-probe developed for MRI that possesses reversible Zn²⁺-binding properties with a rapid dissociation rate (k_off = 845 ± 35 s^-1) for the detection of a wide range of biologically relevant concentrations. Benefiting from the implementation of chemical exchange saturat

SUBMITTER: Tirukoti ND 

PROVIDER: S-EPMC8397314 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature