A Strategy to Conjugate Bioactive Fragments to Cytotoxic Diiron Bis(cyclopentadienyl) Complexes.

ABSTRACT: A series of bioactive molecules were synthesized from the condensation of aspirin or chlorambucil with terminal alkynes bearing alcohol or amine substituents. Insertion of the resulting alkynes into the iron-carbyne bond of readily accessible diiron bis(cyclopentadienyl) μ-aminocarbyne complexes, [1a,b]CF₃SO₃, afforded novel diiron complexes with a bridging vinyliminium ligand, [2-10]CF₃SO₃, functionalized with a bioactive moiety. All compounds were characterized by elemental analysis and IR and multinuclear NMR spectroscopy and in three cases by single-crystal X-ray diffraction. Moreover, the D₂O solubility, stability in D₂O and cell culture media, and octanol-water partition coefficients of diir

SUBMITTER: Schoch S 

PROVIDER: S-EPMC8397425 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature