M2 Macrophage-Based Prognostic Nomogram for Gastric Cancer After Surgical Resection.

ABSTRACT: A good prediction model is useful to accurately predict patient prognosis. Tumor-node-metastasis (TNM) staging often cannot accurately predict prognosis when used alone. Some researchers have shown that the infiltration of M2 macrophages in many tumors indicates poor prognosis. This approach has the potential to predict prognosis more accurately when used in combination with TNM staging, but there is less research in gastric cancer. A multivariate analysis demonstrated that CD163 expression, TNM staging, age, and gender were independent risk factors for overall survival. Thus, these parameters were assessed to develop the nomogram in the training data set, which was tested in the validation and whole data sets. The model showed a high degree of discrimination, calibration, and good clinica

SUBMITTER: Hu J 

PROVIDER: S-EPMC8397443 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature