Genome-Wide Meta-Analysis Identifies Two Novel Risk Loci for Epilepsy.

ABSTRACT: Epilepsy (affects about 70 million people worldwide) is one of the most prevalent brain disorders and imposes a huge economic burden on society. Epilepsy has a strong genetic component. In this study, we perform the largest genome-wide meta-analysis of epilepsy (N = 8,00,869 subjects) by integrating four large-scale genome-wide association studies (GWASs) of epilepsy. We identified three genome-wide significant (GWS) (p < 5 × 10^-8) risk loci for epilepsy. The risk loci on 7q21.11 [lead single nucleotide polymorphism (SNP) rs11978015, p = 9.26 × 10^-9] and 8p23.1 (lead SNP rs28634186, p = 4.39 × 10^-8) are newly identified in the present study. Of note, rs11978015 resides in upstream of GRM3, which encodes glutamate metabotro

SUBMITTER: Song M 

PROVIDER: S-EPMC8397525 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature