Diabetes Mellitus and Cognition: Pathway Analysis in the MEMENTO Cohort.

ABSTRACT:

Objective

To assess the role of biomarkers of Alzheimer disease (AD), neurodegeneration, and small vessel disease (SVD) as mediators in the association between diabetes mellitus and cognition.

Methods

The study sample was derived from MEMENTO, a cohort of French adults recruited in memory clinics and screened for either isolated subjective cognitive complaints or mild cognitive impairment. Diabetes was defined based on blood glucose assessment, use of antidiabetic agent, or self-report. We used structural equation modeling to assess whether latent variables of AD pathology (PET mean amyloid uptake, Aβ₄₂/Aβ₄₀ ratio, and CSF phosphorylated tau), SVD (white matter hyperintensities volume and visual grading), and neurodegeneration (mean cortical thickness,

SUBMITTER: Frison E 

PROVIDER: S-EPMC8397583 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature