Key bacterial taxa and metabolic pathways affecting gut short-chain fatty acid profiles in early life.

ABSTRACT: Infant gut microbiota development affects the host physiology throughout life, and short-chain fatty acids (SCFAs) are promising key metabolites mediating microbiota-host relationships. Here, we investigated dense longitudinally collected faecal samples from 12 subjects during the first 2 years (n = 1048) to identify early life gut SCFA patterns and their relationships with the microbiota. Our results revealed three distinct phases of progression in the SCFA profiles: early phase characterised by low acetate and high succinate, middle-phase characterised by high lactate and formate and late-phase characterised by high propionate and butyrate. Assessment of the SCFA-microbiota relationships revealed that faecal butyrate is associated with increased Clostridiales and breastfeeding cessation,

SUBMITTER: Tsukuda N 

PROVIDER: S-EPMC8397723 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature