Prescription patterns of direct oral anticoagulants and concomitant use of interacting medications in the Netherlands.

ABSTRACT:

Objectives

To describe the prevalence, temporal and regional trends in prescribing direct oral anticoagulants (DOACs) in conjunction with interacting medications.

Methods

We performed a cross-sectional study of pharmacy dispensing data in the Foundation for Pharmaceutical Statistics (SFK) registry on patients who have had a prescription for a DOAC filled at one of 831 randomly selected pharmacies in the Netherlands between Jan 2014-Jan 2019.

Results

We identified 99,211 patients who had a first DOAC prescription filled. Mean age was 71.6 ± 10.9 years, 58% were male. In 2014, 8,293 patients were treated with DOACs, in 2018, 35,415 were newly started on a DOAC. In 2018, the use of apixaban was most common (52%) in the Eastern region, whereas rivaroxaban was most frequen

SUBMITTER: Harskamp RE 

PROVIDER: S-EPMC8397808 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature