Transcriptome sequencing reveals high-salt diet-induced abnormal liver metabolic pathways in mice.

ABSTRACT:

Background

Although salt plays an important role in maintaining the normal physiological metabolism of the human body, many abnormalities in the liver caused by a high-salt diet, especially with normal pathological results, are not well characterized.

Methods

Eight-week-old female C57BL/6 mice were randomly divided into a normal group and a high salt group. These groups were then fed with normal or sodium-rich chow (containing 6% NaCl) for 6 weeks. Liver injury was evaluated, and the influences of a high-salt diet on the liver were analyzed by transcriptome sequencing at the end of week 6.

Results

We found that although no liver parenchymal injury could be found after high-salt feeding, many metabolic abnormalities had formed based on transcriptome sequencing results.

SUBMITTER: Li Y 

PROVIDER: S-EPMC8397858 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature