Design of a Multi-epitope Vaccine Against Acinetobacter baumannii Using Immunoinformatics Approach.

ABSTRACT: Acinetobacter baumannii is one of the most successful pathogens causing nosocomial infections and has significantly multidrug-resistant. So far, there are no certain treatments to protect against infection with A. baumannii, therefore an effective A. baumannii vaccine needed. The purpose of this study was to predict antigenic epitopes of CarO protein for designing the A. baumannii vaccine using immunoinformatics analysis. CarO protein is one of the most important factors in the resistance against the antibiotic Carbapenem. In this study, T and B-cell epitopes of CarO protein were predicted and screened based on the antigenicity, toxicity, allergenicity features. The epitopes were linked by suitable linkers. Four different adjuvants we

SUBMITTER: Touhidinia M 

PROVIDER: S-EPMC8397861 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature