Nox2-derived superoxide radical is crucial to control acute Trypanosoma cruzi infection.

ABSTRACT: Trypanosoma cruzi is a flagellated protozoan that undergoes a complex life cycle between hematophagous insects and mammals. In humans, this parasite causes Chagas disease, which in thirty percent of those infected, would result in serious chronic pathologies and even death. Macrophages participate in the first stages of infection, mounting a cytotoxic response which promotes massive oxidative damage to the parasite. On the other hand, T. cruzi is equipped with a robust antioxidant system to repeal the oxidative attack from macrophages. This work was conceived to explicitly assess the role of mammalian cell-derived superoxide radical in a murine model of acute infection by T. cruzi. Macrophages derived from Nox2-deficient (gp91^phox-/-) mice produced marginal amounts of superoxide

SUBMITTER: Prolo C 

PROVIDER: S-EPMC8397891 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature