External Evaluation of Population Pharmacokinetic Models and Bayes-Based Dosing of Infliximab.

ABSTRACT: Despite the well-demonstrated efficacy of infliximab in inflammatory diseases, treatment failure remains frequent. Dose adjustment using Bayesian methods has shown in silico its interest in achieving target plasma concentrations. However, most of the published models have not been fully validated in accordance with the recommendations. This study aimed to submit these models to an external evaluation and verify their predictive capabilities. Eight models were selected for external evaluation, carried out on an independent database (409 concentrations from 157 patients). Each model was evaluated based on the following parameters: goodness-of-fit (comparison of predictions to observations), residual error model (population weighted residuals (PWRES), individual weighted residuals (IWRES), an

SUBMITTER: Konecki C 

PROVIDER: S-EPMC8398005 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature