Impact of Powder Properties on the Rheological Behavior of Excipients.

ABSTRACT: With the emergence of quality by design in the pharmaceutical industry, it becomes imperative to gain a deeper mechanistic understanding of factors impacting the flow of a formulation into tableting dies. Many flow characterization techniques are present, but so far only a few have shown to mimic the die filling process successfully. One of the challenges in mimicking the die filling process is the impact of rheological powder behavior as a result of differences in flow field in the feeding frame. In the current study, the rheological behavior was investigated for a wide range of excipients with a wide range of material properties. A new parameter for rheological behavior was introduced, which is a measure for the change in dynamic cohesive index upon changes in flow field. Particle size d

SUBMITTER: Janssen PHM 

PROVIDER: S-EPMC8398033 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature