Design, Synthesis, and Anticancer Activity Studies of Novel Quinoline-Chalcone Derivatives.

ABSTRACT: The chalcone and quinoline scaffolds are frequently utilized to design novel anticancer agents. As the continuation of our work on effective anticancer agents, we assumed that linking chalcone fragment to the quinoline scaffold through the principle of molecular hybridization strategy could produce novel compounds with potential anticancer activity. Therefore, quinoline-chalcone derivatives were designed and synthesized, and we explored their antiproliferative activity against MGC-803, HCT-116, and MCF-7 cells. Among these compounds, compound 12e exhibited a most excellent inhibitory potency against MGC-803, HCT-116, and MCF-7 cells with IC₅₀ values of 1.38, 5.34, and 5.21 µM, respectively. The structure-activity relationship of quinoline-chalcone derivatives was prelimin

SUBMITTER: Guan YF 

PROVIDER: S-EPMC8398129 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature