Nanoradiopharmaceuticals Based on Alpha Emitters: Recent Developments for Medical Applications.

ABSTRACT: The application of nanotechnology in nuclear medicine offers attractive therapeutic opportunities for the treatment of various diseases, including cancer. Indeed, nanoparticles-conjugated targeted alpha-particle therapy (TAT) would be ideal for localized cell killing due to high linear energy transfer and short ranges of alpha emitters. New approaches in radiolabeling are necessary because chemical radiolabeling techniques are rendered sub-optimal due to the presence of recoil energy generated by alpha decay, which causes chemical bonds to break. This review attempts to cover, in a concise fashion, various aspects of physics, radiobiology, and production of alpha emitters, as well as highlight the main problems they present, with possible new approaches to mitigate those problems. Special

SUBMITTER: Trujillo-Nolasco M 

PROVIDER: S-EPMC8398190 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature