Multilayer Thin-Film Optical Filters for Reflectance-Based Malaria Diagnostics.

ABSTRACT: Malaria diagnosis relies on optical microscopy and/or rapid diagnostic tests based on detecting specific malaria antigens. The clinical sensitivity of these methods is highly dependent on parasite density, with low levels of detection at low parasite density, challenging the worldwide malaria elimination efforts. Therefore, there is a need for diagnostic methods with higher sensitivity, demanding innovative diagnostics devices able to detect malaria at low parasite density and at early stages of the disease. We propose an innovative optical device for malaria diagnosis, based on optical reflectance spectrophotometry, for the detection of parasites through the quantification of haemozoin. For this purpose, a set of eight thin-film optical filters, based on multilayer stacks of MgO/TiO2 and

SUBMITTER: Costa MS 

PROVIDER: S-EPMC8398211 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature