Family SES Is Associated with the Gut Microbiome in Infants and Children.

ABSTRACT:

Background

While early life exposures such as mode of birth, breastfeeding, and antibiotic use are established regulators of microbiome composition in early childhood, recent research suggests that the social environment may also exert influence. Two recent studies in adults demonstrated associations between socioeconomic factors and microbiome composition. This study expands on this prior work by examining the association between family socioeconomic status (SES) and host genetics with microbiome composition in infants and children.

Methods

Family SES was used to predict a latent variable representing six genera abundances generated from whole-genome shotgun sequencing. A polygenic score derived from a microbiome genome-wide association study was included to control for pot

SUBMITTER: Lewis CR 

PROVIDER: S-EPMC8398307 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature