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New Cytotoxic Cytochalasans from a Plant-Associated Fungus Chaetomium globosum kz-19.

ABSTRACT: Four new cytochalasans, phychaetoglobins A-D (1-4), together with twelve known cytochalasans (5-16), were isolated from a mangrove-associated fungus Chaetomium globosum kz-19. The new structures were elucidated on the basis of extensive 1D and 2D NMR, HR ESIMS spectroscopic analyses, and electronic circular dichroism (ECD) calculations. The absolute configuration of 2 was established by application of Mosher's method. Compounds 4-8 exhibited moderate cytotoxicities against A549 and HeLa cell lines with the IC50 values less than 20 μM.

SUBMITTER: Li T

PROVIDER: S-EPMC8398356 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature

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New Cytotoxic Cytochalasans from a Plant-Associated Fungus Chaetomium globosum kz-19.

Li Tantan T Wang Yun Y Li Li L Tang Mengyue M Meng Qinghong Q Zhang Cun C Hua Erbing E Pei Yuehu Y Sun Yi Y

Marine drugs 20210731 8

Four new cytochalasans, phychaetoglobins A-D (1-4), together with twelve known cytochalasans (5-16), were isolated from a mangrove-associated fungus Chaetomium globosum kz-19. The new structures were elucidated on the basis of extensive 1D and 2D NMR, HR ESIMS spectroscopic analyses, and electronic circular dichroism (ECD) calculations. The absolute configuration of 2 was established by application of Mosher's method. Compounds 4-8 exhibite ...[more]

PMID: 34436277

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