Novel Therapies for Tongue Squamous Cell Carcinoma Patients with High-Grade Tumors.

ABSTRACT:

Background

Tongue squamous cell carcinoma (TSCC) patients with high-grade tumors usually suffer from high occurrence and poor prognosis. The current study aimed at finding the biomarkers related to tumor grades and proposing potential therapies by these biomarkers.

Methods

The mRNA expression matrix of TSCC samples from The Cancer Genome Atlas (TCGA) database was analyzed to identify hub proteins related to tumor grades. The mRNA expression patterns of these hub proteins between TSCC and adjacent control samples were validated in three independent TSCC data sets (i.e., GSE9844, GSE30784, and GSE13601). The correlation between cell cycle index and immunotherapy efficacy was tested on the IMvigor210 data set. Based on the structure of hub proteins, virtual screening was applie

SUBMITTER: Li Y 

PROVIDER: S-EPMC8398384 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature