TMPRSS6 rs855791 Polymorphism Status in Children with Celiac Disease and Anemia.

ABSTRACT: Celiac disease (CD) is an autoimmune chronic inflammatory disease occurring in genetically predisposed individuals in response to the intake of gluten. Clinical presentation can be heterogeneous. Iron-deficient anemia (IDA) is one of the most common extra-intestinal manifestations of CD. Although IDA usually reverts with a gluten-free diet (GFD), some patients show persistent IDA, the mechanisms of which are poorly understood. Recent studies suggest an association between the rs855791 polymorphism in the TMPRSS6 gene and persistent IDA in adults with CD. The current study aimed to assess the potential link between rs855791 and persistent IDA in pediatric patients with CD. The study included 106 children diagnosed with CD between 2015 and 2019. Clinical and blood parameters (includin

SUBMITTER: Urbaszek K 

PROVIDER: S-EPMC8398390 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature