Synthesis and Biological Evaluation of Amidinourea Derivatives against Herpes Simplex Viruses.
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ABSTRACT:
SUBMITTER: Toscani A
PROVIDER: S-EPMC8398393 | biostudies-literature | 2021 Aug
REPOSITORIES: biostudies-literature
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Synthesis and Biological Evaluation of Amidinourea Derivatives against Herpes Simplex Viruses.
Toscani Anita A Denaro Rossana R Pacheco Sergio Fernando Castillo SFC Biolatti Matteo M Anselmi Silvia S Dell'Oste Valentina V Castagnolo Daniele D
Molecules (Basel, Switzerland) 20210814 16
Current therapy against herpes simplex viruses (HSV) relies on the use of a few nucleoside antivirals such as acyclovir, famciclovir and valacyclovir. However, the current drugs are ineffective against latent and drug-resistant HSV infections. A series of amidinourea compounds, designed as analogues of the antiviral drug moroxydine, has been synthesized and evaluated as potential non-nucleoside anti-HSV agents. Three compounds showed micromolar activity against HSV-1 and low cytotoxicity, turnin ...[more]
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