LAG-3 Expression Predicts Outcome in Stage II Colon Cancer.

ABSTRACT: LAG-3 is an inhibitory immune checkpoint molecule that suppresses T cell activation and inflammatory cytokine secretion. T cell density in the tumor microenvironment of colon cancer plays an important role in the host's immunosurveillance. We therefore hypothesized that LAG-3 expression on tumor-infiltrating lymphocytes (TILs) predicts outcome in patients with stage II colon cancer. Immunohistochemical staining for LAG-3 was performed on tissue microarrays (TMAs) of formalin-fixed paraffin-embedded tissue from 142 stage II colon cancer patients. LAG-3 expression was assessed in TILs within both the tumor front and tumor center and scored as either positive or negative. The primary endpoint was disease-free survival (DFS). In patients diagnosed with stage II colon cancer, the presence of LA

SUBMITTER: Rhyner Agocs G 

PROVIDER: S-EPMC8398428 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature