Ontology highlight
ABSTRACT:
SUBMITTER: He Z
PROVIDER: S-EPMC8398431 | biostudies-literature | 2021 Aug
REPOSITORIES: biostudies-literature
He Zhili Z Li Jiajia J Gong Saisai S Xing Li L Sun Yakun Y Wang Jianxin J Li Tao T Ning Nianzhi N Zhang Liangyan L Yu Wenjing W Luo Deyan D Wang Hui H
Microorganisms 20210819 8
As an essential member of the B7 family, V-set and immunoglobulin domain-containing 4 (VSIG4) is expressed explicitly in tissue-resident macrophages (TRMs) and plays an essential role in maintaining the homeostasis of the environmental immune system. Here, we demonstrate that gene-targeted VSIG4-deficient mice infected with <i>Enterohemorrhagic Escherichia coli</i> (EHEC) display reduced bacterial burden. To reveal the role of VSIG4 in the fight against EHEC infection, we collected mice feces an ...[more]