Ruthenium Complexes: An Alternative to Platinum Drugs in Colorectal Cancer Treatment.

ABSTRACT: Colorectal cancer (CRC) is one of the intimidating causes of death around the world. CRC originated from mutations of tumor suppressor genes, proto-oncogenes and DNA repair genes. Though platinum (Pt)-based anticancer drugs have been widely used in the treatment of cancer, their toxicity and CRC cells' resistance to Pt drugs has piqued interest in the search for alternative metal-based drugs. Ruthenium (Ru)-based compounds displayed promising anticancer activity due to their unique chemical properties. Ru-complexes are reported to exert their anticancer activities in CRC cells by regulating different cell signaling pathways that are either directly or indirectly associated with cell growth, division, proliferation, and migration. Additionally, some Ru-based drug candidates showed higher po

SUBMITTER: Mahmud KM 

PROVIDER: S-EPMC8398452 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature