Ontology highlight
ABSTRACT:
SUBMITTER: Kim SY
PROVIDER: S-EPMC8398538 | biostudies-literature | 2021 Aug
REPOSITORIES: biostudies-literature
Kim So Young SY Shin Myoung-Sook MS Kim Geum Jin GJ Kwon Hyukbean H Lee Myong Jin MJ Han Ah-Reum AR Nam Joo-Won JW Jung Chan-Hun CH Kang Ki Sung KS Choi Hyukjae H
Marine drugs 20210819 8
The epithelial-mesenchymal transition (EMT) of cancer cells is a crucial process in cancer cell metastasis. An <i>Aquimarina</i> sp. MC085 extract was found to inhibit A549 human lung cancer cell invasion, and caprolactin C (<b>1</b>), a new natural product, α-amino-ε-caprolactam linked to 3-methyl butanoic acid, was purified through bioactivity-guided isolation of the extract. Furthermore, its enantiomeric compound, <i>ent</i>-caprolactin C (<b>2</b>), was synthesized. Both <b>1</b> and <b>2</b ...[more]