Investigating Global Lipidome Alterations with the Lipid Network Explorer.

ABSTRACT: Lipids play an important role in biological systems and have the potential to serve as biomarkers in medical applications. Advances in lipidomics allow identification of hundreds of lipid species from biological samples. However, a systems biological analysis of the lipidome, by incorporating pathway information remains challenging, leaving lipidomics behind compared to other omics disciplines. An especially uncharted territory is the integration of statistical and network-based approaches for studying global lipidome changes. Here we developed the Lipid Network Explorer (LINEX), a web-tool addressing this gap by providing a way to visualize and analyze functional lipid metabolic networks. It utilizes metabolic rules to match biochemically connected lipids on a species level and combine it

SUBMITTER: Kohler N 

PROVIDER: S-EPMC8398636 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature