Ontology highlight
ABSTRACT:
SUBMITTER: Penhallurick RW
PROVIDER: S-EPMC8399027 | biostudies-literature | 2021 Aug
REPOSITORIES: biostudies-literature
Penhallurick Ryan W RW Durnal Maya D MD Harold Alliyah A Ichiye Toshiko T
Microorganisms 20210811 8
Enzymes from extremophilic microbes that live in extreme conditions are generally adapted so that they function under those conditions, although adaptations for extreme temperatures and pressures can be difficult to unravel. Previous studies have shown mutation of Asp27 in <i>Escherichia coli</i> dihydrofolate reductase (DHFR) to Glu27 in <i>Moritella profunda</i> (Mp). DHFR enhances activity at higher pressures, although this may be an adaptation for cold. Interestingly, MpDHFR unfolds at ~70 M ...[more]