Laser Scribing Fabrication of Graphitic Carbon Biosensors for Label-Free Detection of Interleukin-6.

ABSTRACT: Interleukin-6 (IL-6) is an important immuno-modulating cytokine playing a pivotal role in inflammatory processes in disease induction and progression. As IL-6 serves as an important indicator of disease state, it is of paramount importance to develop low cost, fast and sensitive improved methods of detection. Here we present an electrochemical immunosensor platform based on the use of highly porous graphitic carbon electrodes fabricated by direct laser writing of commercial polyimide tapes and chemically modified with capture IL-6 antibodies. The unique porous and 3D morphology, as well as the high density of edge planes of the graphitic carbon electrodes, resulted in a fast heterogeneous electron transfer (HET) rate, k0 = 0.13 cm/s. The resulting immunosensor showed a linear response to l

SUBMITTER: Tan PS 

PROVIDER: S-EPMC8399033 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature