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H₂O₂ Induces Major Phosphorylation Changes in Critical Regulators of Signal Transduction, Gene Expression, Metabolism and Developmental Networks in Aspergillus nidulans.

ABSTRACT: Reactive oxygen species (ROS) regulate several aspects of cell physiology in filamentous fungi including the antioxidant response and development. However, little is known about the signaling pathways involved in these processes. Here, we report Aspergillus nidulans global phosphoproteome during mycelial growth and show that under these conditions, H₂O₂ induces major changes in protein phosphorylation. Among the 1964 phosphoproteins we identified, H₂O₂ induced the phosphorylation of 131 proteins at one or more sites as well as the dephosphorylation of a larger set of proteins. A detailed analysis of these phosphoproteins shows that H₂O₂ affected the phosphorylation of critical regulatory nodes of phosphoinositide, MAP

SUBMITTER: Carrasco-Navarro U

PROVIDER: S-EPMC8399174 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature

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H₂O₂ Induces Major Phosphorylation Changes in Critical Regulators of Signal Transduction, Gene Expression, Metabolism and Developmental Networks in Aspergillus nidulans.

OmicsDI is part of the ELIXIR infrastructure

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H2O2 Induces Major Phosphorylation Changes in Critical Regulators of Signal Transduction, Gene Expression, Metabolism and Developmental Networks in Aspergillus nidulans.

OmicsDI is part of the ELIXIR infrastructure

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H₂O₂ Induces Major Phosphorylation Changes in Critical Regulators of Signal Transduction, Gene Expression, Metabolism and Developmental Networks in Aspergillus nidulans.