Ontology highlight
ABSTRACT:
SUBMITTER: Bouz G
PROVIDER: S-EPMC8399443 | biostudies-literature | 2021 Aug
REPOSITORIES: biostudies-literature
Bouz Ghada G Bouz Sarah S Janďourek Ondřej O Konečná Klára K Bárta Pavel P Vinšová Jarmila J Doležal Martin M Zitko Jan J
Pharmaceuticals (Basel, Switzerland) 20210804 8
Despite the established treatment regimens, tuberculosis remains an alarming threat to public health according to WHO. Novel agents are needed to overcome the increasing rate of resistance and perhaps achieve eradication. As part of our long-term research on pyrazine derived compounds, we prepared a series of their ortho fused derivatives, <i>N</i>-phenyl- and <i>N</i>-benzyl quinoxaline-2-carboxamides, and evaluated their in vitro antimycobacterial activity. In vitro activity against <i>Mycobac ...[more]