Autophagy Deficiency by Atg4B Loss Leads to Metabolomic Alterations in Mice.

ABSTRACT: Autophagy is an essential protective mechanism that allows mammalian cells to cope with a variety of stressors and contributes to maintaining cellular and tissue homeostasis. Due to these crucial roles and also to the fact that autophagy malfunction has been described in a wide range of pathologies, an increasing number of in vivo studies involving animal models targeting autophagy genes have been developed. In mammals, total autophagy inactivation is lethal, and constitutive knockout models lacking effectors of this route are not viable, which has hindered so far the analysis of the consequences of a systemic autophagy decline. Here, we take advantage of atg4b-/- mice, an autophagy-deficient model with only partial disruption of the process, to assess the effects of systemic reduction of

SUBMITTER: Martinez-Garcia GG 

PROVIDER: S-EPMC8399495 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature