Longitudinal development of incident gout from low-normal baseline serum urate concentrations: individual participant data analysis.

ABSTRACT:

Introduction

Elevated serum urate (SU) concentration is the central risk factor for the development of gout. The aim of this study was to examine the incidence of gout in people with low and normal SU levels (< 7.00 mg/dL).

Methods

Longitudinal cohort data from the Atherosclerosis Risk in Communities Study (ARIC), Coronary Artery Risk Development in Young Adults Study (CARDIA), and both the Original and Offspring cohorts of the Framingham Heart Study (FHS) were used to determine incident gout by baseline SU over 3, 5, 10, 12 and 15 year periods. A Cox proportional hazards model with covariables of age, gender, ethnicity, and cohort was calculated to report the hazard ratios (HR) for incident gout.

Results

The incidence of gout at 15 years for a baseline SU < 4.00 mg/d

SUBMITTER: Robinson PC 

PROVIDER: S-EPMC8399746 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature