Non-Coding RNAs and Splicing Activity in Testicular Germ Cell Tumors.

ABSTRACT: Testicular germ cell tumors (TGCTs) are the most common tumors in adolescent and young men. Recently, genome-wide studies have made it possible to progress in understanding the molecular mechanisms underlying the development of tumors. It is becoming increasingly clear that aberrant regulation of RNA metabolism can drive tumorigenesis and influence chemotherapeutic response. Notably, the expression of non-coding RNAs as well as specific splice variants is deeply deregulated in human cancers. Since these cancer-related RNA species are considered promising diagnostic, prognostic and therapeutic targets, understanding their function in cancer development is becoming a major challenge. Here, we summarize how the different expression of RNA species repertoire, including non-coding RNAs and prot

SUBMITTER: Barchi M 

PROVIDER: S-EPMC8399856 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature