Modulating the Thermoresponse of Polymer-Protein Conjugates with Hydrogels for Controlled Release.

ABSTRACT: Sustained release is being explored to increase plasma and tissue residence times of polymer-protein therapeutics for improved efficacy. Recently, poly(oligo(ethylene glycol) methyl ether methacrylate) (PEGMA) polymers have been established as potential PEG alternatives to further decrease immunogenicity and introduce responsive or sieving properties. We developed a drug delivery system that locally depresses the lower critical solution temperature (LCST) of PEGMA-protein conjugates within zwitterionic hydrogels for controlled release. Inside the hydrogel the conjugates partially aggregate through PEGMA-PEGMA chain interactions to limit their release rates, whereas conjugates outside of the hydrogel are completely solubilized. Release can therefore be tuned by altering hydrogel components

SUBMITTER: Huynh V 

PROVIDER: S-EPMC8399950 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature